![]() Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia. A group of A and AS level students were given a taste of life as a scientific researcher this month when they attended an outreach day in the Department of Metabolic Medicine. Preprandial levels of the appetite-stimulatory hormone, ghrelin, were significantly suppressed by OXM (mean reduction, 44 +/- 10% of postprandial decrease P < 0.0001). Professor Maud LemoineHead of Digestive Disease. 6N3, 6th Floor, Commonwealth Building, Hammersmith Campus. His research investigates novel aspects of endocrine control of obesity and reproductive function. OXM did not cause nausea or affect food palatability. Waljit Dhillo is a Professor in Endocrinology & Metabolism, Consultant Endocrinologist and an NIHR Research Professor. In addition, cumulative 12-h energy intake was significantly reduced by infusion of OXM (mean decrease, 11.3 +/- 6.2% P < 0.05). Steve Bloom is the Head of Drug Development, Dept Metabolism, Digestion & Reproduction and Clinical Director of Pathology for North West London Pathology at Imperial College Healthcare NHS Trust, serving six major acute hospitals. Infusion of OXM significantly reduced ad libitum energy intake at a buffet meal (mean decrease, 19.3 +/- 5.6% P < 0.01) and caused a significant reduction in scores for hunger. We investigated the effect of iv OXM (3.0 pmol/kg.min) on appetite and food intake in 13 healthy subjects (body mass index, 22.5 +/- 0.9 kg/m(2)) in a randomized, double-blind, placebo-controlled, cross-over study. He received his medical degree and trained in Endocrinology in the University of Barcelona School of Medicine. ![]() He is also a Wellcome Trust Senior Investigator. Central injection of OXM reduces food intake and weight gain in rodents, suggesting that OXM signals food ingestion to hypothalamic appetite-regulating circuits. Professor Ferrer is chair in Genetics and Medicine, Head of the Section of Epigenomics and Disease, and Lead for Genetics and Genomics in the NIHR Imperial Biomedical Research Centre. Oxyntomodulin (OXM) is released from the gut postprandially, in proportion to energy intake, and circulating levels of OXM are elevated in several conditions associated with anorexia. ![]()
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